Stroke & Vascular dementia
Cognitive deficits following stroke are a major cause of functional impairment and disability, reducing the quality of life of patients and their carers. Our focus has been on understanding the mechanisms underlying the syndromes of visual inattention (including visual neglect) and developing treatments for this.
More recently we have been investigating apathy and disorders of motivation in patients with small vessel cerebrovascular disease, vascular dementia and CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) - an inherited condition that is often associated with altered cognition and motivation.
We are performing research on:
If you want to get involved or find out more about our research based at Oxford University and the John Radcliffe Hospital, please write to:
Professor Masud Husain, Nuffield Dept Clinical Neurosciences, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU or
email: masud.husain@ndcn.ox.ac.uk
NEW BOOK
Husain M & Schott J eds. (2016) Oxford Textbook of Cognitive Neurology & Dementia. Oxford University Press, Oxford.
You can find out more about our research on inattention following stroke and related topics by clicking on the titles below.
PUBLICATIONS LISTED HERE ARE AVAILABLE FOR PERSONAL USE ONLY
Reviews & Commentaries
Le Heron C, Holroyd CB, Salamone J, Husain M (2018) Brain mechanisms underlying apathy. J Neurol Neurosurg Psychiatry (Epub ahead of print) [Review]
Husain M, Roiser R (2018) The neuroscience of apathy and anhedonia: A transdiagnostic approach. Nature Reviews Neuroscience (Epub ahead of print) [Review]
Husain M | Scholarpedia article: Hemispatial neglect [Review]
Husain M, Mehta MA. (2011) Cognitive enhancement by drugs in health and disease. Trends in Cognitive Sciences 15: 28-36. PMID:21146447 PMC3020278 [Review]
Singh-Curry V, Husain M. (2010) Rehabilitation in practice: Hemispatial neglect: approaches to rehabilitation. Clinical Rehabilitation 24: 675-684. PMID:20702515 [Review]
Cheeran B, Cohen L, Dobkin B, Ford G, Greenwood R, Howard D, Husain M, Macleod M, Nudo R, Rothwell J, Rudd A, Teo J, Ward N, Wolf S. (2009) The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke. Neurorehabilitation and Neural Repair 23: 97-107. PMID:19189939 [Review]
Malhotra P, Coulthard E, Husain M. (2006) Hemispatial neglect, balance and eye movement control. Current Opinion in Neurology 19: 14-20. PMID: 16415672 [Review]
Coulthard E, Parton A, Husain M. (2006) Action control in visual neglect. Neuropsychologia 44: 2717-33. PMID: 16368117 [Review]
Nachev P, Husain M. (2006) Disorders of visual attention and the posterior parietal cortex. Cortex 42: 766-773. PMID: 16909637 [Review]
Jackson SR, Husain M. (2006) Visuomotor functions of the posterior parietal cortex. Neuropsychologia 44: 2589-2593. PMID: 16962619 [Review]
Parton A, Coulthard E, Husain M. (2005) Neuropharmacological modulation of cognitive deficits after brain damage. Current Opinion in Neurology 18: 675-80. PMID: 16280679 [Review]
Parton A, Husain M. (2004) Spatial Neglect. Advances in Clinical Neuroscience & Rehabilitation 4: 17-18 [Review]
Parton A, Malhotra P, Husain M. (2004) Hemispatial Neglect. Journal of Neurology, Neurosurgery & Psychiatry 75: 13-21. PMID:14707298 PMC1757480 [Review]
Husain M, Rorden C. (2003) Non-spatially lateralized mechanisms in hemispatial neglect. Nature Reviews Neuroscience 4: 26-36. PMID:12511859 [Review]
Husain M. (2002) Cognitive Neuroscience of Hemispatial neglect. Cognitive Neuropsychiatry 7: 195-209. PMID:16571537 [Review]
Research papers
Erfanian Abdoust M, Knecht S, Husain M, Le Heron C, Jocham G, Studer B (2024) Effort-based decision making and motivational deficits in stroke patients. Brain Cogn. 175:106123. PMID: 38183905
Tai XY, Torzillo E, Lyall DM, Manohar S, Husain M, Sen A (2023) Association of Dementia Risk With Focal Epilepsy and Modifiable Cardiovascular Risk Factors. JAMA Neurol. 80: 445–454. PMC10043806
Moore M, Milosevich E, Beisteiner R, Bowen A, Checketts M, Demeyere N, Fordell H, Godefroy O,Laczó J, Rich T, Williams L, Woodward-Nutt K, Husain M. (2022) Rapid screening for neglect following stroke: A systematic search and European Academy of Neurology recommendations. Eur J Neurol 29:2596-2606 PMID: 35510782
Tai XY, Veldsman M, Lyall DM, Littlejohns TJ, Langa KM, Husain M, Ranson J, Llewellyn DJ (2022) Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Lancet Healthy Longev. 3: e428–e436. PMC9184258
Saleh Y, Le Heron C, Petitet P, Veldsman M, Drew D, Plant O, Schulz U, Sen A, Rothwell PM, Manohar S, Husain M (2021) Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making. Brain 144:1247-62. PMID: 33734344
Veldsman M, Tai XY, Nichols T, Smith S, Peixoto J, Manohar S, Husain M (2020) Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing. Nature Communications 11:4340. PMID: 32895386
Tay J, Morris RG, Tuladhar AM, Husain M, de Leeuw FE, Markus HS (2020) Apathy, but not depression, predicts all-cause dementia in small vessel disease. J Neurol Neurosurg Psychiatry 91:953-9. PMID: 32651249
Sundaresan V, Zamboni G, Le Heron C, Rothwell PM, Husain M, Battaglini M, De Stefano N, Jenkinson M, Griffanti L (2019) Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding. Neuroimage Clinical (Epub ahead of print) PMID: 31376518
Moore MJ, Vancleef K, Shalev N, Husain M, Demeyere N (2019) When neglect is neglected: NIHSS observational measure lacks sensitivity in identifying post-stroke unilateral neglect. J Neurol Neurosurg Psychiat (Epub ahead of print) PMID:30674542
Tay J, Tuladhar AM, Hollocks MJ, Brookes RL, Tozer DJ, Barrick TR, Husain M, de Leeuw FE, Markus HS (2019) Apathy is associated with large-scale white matter network disruption in small vessel disease. Neurology 92:e1157-e1167
Le Heron C, Manohar S, Plant O, Muhammed K, Griffanti L, Nemeth A, Douaud G, Markus HS, Husain M (2018) Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain 141:3193-3210 PMID:30346491
Sen A, Capelli V, Husain M (2018) Cognition and dementia in older patients with epilepsy. Brain 141:1592-1608.
Dalmaijer ES, Li KMS, Gorgoraptis N, Leff AP, Cohen DL, Parton AD, Husain M, Malhotra PA (2018) Randomised, double-blind, placebo-controlled crossover study of single-dose guanfacine in unilateral neglect following stroke. J Neurol Neurosurg Psychiatry 89:593-8.
Xu T, Jager HR, Husain M, Rees G, Nachev P (2017) High-dimensional therapeutic inference in the focally damaged brain. Brain (Epub ahead of print).
Manohar SG, Husain M (2016) Human ventromedial prefrontal lesions alter incentivisation by reward. Cortex 76: 104-20 PMID: 26874940.
Hollocks MJ, Lawrence AJ, Brookes RL, Barrick TR, Morris RG, Husain M, Markus HS (2015) Differential relationships between apathy and depression with white matter microstructure changes and functional outcomes. Brain (Epub ahead of print) PMID: 26490330.
Dalmaijer ES, Van der Stigchel S, Nijboer TCW, Cornelissen THW, Husain M. (2014) Cancellation Tools: All-in-one software for administration and analysis of cancellation tasks. Behavior research methods (Epub ahead of print) PMID: 25381020
Ong YH, Acquin‐Courtois S, Gorgoraptis N, Bays PM, Husain M, Leff AP. (2014) Eye‐Search: A web‐based therapy that improves visual search in hemianopia. Annals of Clinical and Translational Neurology 2, 74-78. PMID: 25642437
Russell C, Malhotra P, Deidda C, Husain M. (2012) Dynamic attention modulation of vision across space and time after right hemisphere stroke and in aging. Cortex 49: 1874-83. PMID:23245427
Gorgoraptis N, Mah Y-H, Machner B, Singh-Curry V, Malhotra P, Hadji-Michael M, Cohen D, Simister R, Nair A, Kulinskaya E, Ward N, Greenwood R, Husain M. (2012) The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke. Brain 135: 2478-91. PMID:22761293 PMC3407421
Jacquin-Courtois S, Bays PM, Salemme R, Leff AP, Husain M. (2012) Rapid compensation of visual search strategy in patients with chronic visual field defects. Cortex 49(4):994-1000. PMID:22626007
Machner B, Mah Y-H, Gorgoraptis N, Husain M. (2012). How reliable is repeated testing for hemispatial neglect? Implications for clinical follow-up and treatment trials. Journal of Neurology, Neurosurgery and Psychiatry 83: 1032-1034. PMID:22923514
Ong YH, Brown MM, Robinson P, Plant GT, Husain M, Leff AP. (2012) Read-Right: a “web app” that improves reading speeds in patients with hemianopia. Journal of Neurology 259:2611-5. PMID:22688568 PMC3506196
Bays PM, Singh-Curry V, Gorgoraptis N, Driver J, Husain M. (2010) Integration of goal- and stimulus-related visual signals revealed by damage to human parietal cortex. Journal of Neuroscience 30: 5968-5978. PMID:20427656
Russell C, Deidda C, Malhotra P, Crinion J, Merola S, Husain M. (2010) A deficit of spatial remapping in constructional apraxia after right hemisphere stroke. Brain 133: 1239-1251. PMID:20375139
Kennett S, Rorden C, Husain M, Driver J. (2010) Crossmodal visual-tactile extinction: Modulation by posture implicates biased competition in proprioceptively reconstructed space. Journal of Neuropsychology 4: 15-32. PMID:19822034 PMC3229705
Malhotra P, Coulthard EJ, Husain M. (2009) Role of right posterior parietal cortex in maintaining attention to spatial locations over time. Brain 132: 645-660. PMID:19158107 PMC2664449
Mannan SK, Kennard C, Husain M. (2009) The role of visual salience in directing eye movements in visual object agnosia. Current Biology 19: R247-R248. PMID:19321139
Jackson GM, Swainson R, Mort D, Husain M, Jackson SR. (2009) Attention, competition, and the parietal lobes: insights from Balint's syndrome. Psychological Research 73: 263-270. PMID:19156438
Vuilleumier P, Schwartz S, Verdon V, Maravita A, Hutton C, Husain M, Driver J. Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. Current Biology 18: 1525-9.
Nachev P, Coulthard E, Jäger HR, Kennard C, Husain M. (2008) Enantiomorphic normalization of focally lesioned brains. NeuroImage 39: 1215-1226. PMID:18023365 PMC2658465
Sarri M, Greenwood R, Kalra L, Papps B, Husain M, Driver J (2008) Prism adaptation aftereffects in stroke patients with spatial neglect: pathological effects on subjective straight ahead but not visual open-loop pointing. Neuropsychologia 46: 1069-1080. PMID: 8083203 PMC2600424
Hodgson T, Chamberlain M, Parris B, James M, Gutowski N, Husain M, Kennard C. (2007) The role of the ventrolateral frontal cortex in inhibitory oculomotor control. Brain 130: 1525-37. PMID:17452376
Maravita A, Posteraro L, Husain M, Vuilleumier P, Schwartz S, Driver J. (2007) Looking at human eyes affects contralesional stimulus processing after right hemispheric stroke. Neurology 69: 1619-1621 PMID:17938372 PMC2600428
Vuilleumier P, Sergent C, Schwartz S, Valenza N, Girardi M, Husain M, Driver J. (2008) Impaired perceptual memory of locations across gaze-shifts in patients with unilateral neglect. Journal of Cognitive Neuroscience 19:1388-406. PMID:17651010 PMC2601183
Parton A, Nachev P, Hodgson T, Mort D, Thomas D, Ordidge R, Morgan P, Jackson S, Rees G, Husain M. (2007) Role of the human supplementary eye field in the control of saccadic eye movements. Neuropsychologia 45: 997-1008. PMID:17069864 PMC2649282
Coulthard E, Parton A, Husain M. (2007) The modular architecture of the neglect syndrome: Implications for action control in visual neglect. Neuropsychologia 45: 1982-1984.
Parton A, Malhotra P, Nachev P, Ames D, Ball J, Chataway J, Husain M. (2006) Space Re-exploration in Hemispatial Neglect. NeuroReport 17: 833-6. PMID:16708024
Malhotra P, Parton A, Greenwood R, Husain M. (2006) Noradrenergic modulation of space exploration in visual neglect. Annals of Neurology 59: 186-90. PMID:16261567
Bird CM, Malhotra P, Parton A, Coulthard E, Rushworth MF, Husain M. (2006) Visual neglect after right posterior cerebral artery infarction. Journal of Neurology, Neurosurgery and Psychiatry 77: 1008-1012. PMID:16772354 PMC2077751
Newport R, Brown L, Husain M, Mort D, Jackson SR. (2006) The role of the posterior parietal lobe in prism adaptation: Failure to adapt to optical prisms in a patient with bilateral damage to posterior parietal cortex. Cortex 42: 720-729. PMID:16909632
Jackson GM, Shepherd T, Mueller SC, Husain M, Jackson SR. (2006) Dorsal simultanagnosia: An impairment of visual processing or visual awareness? Cortex 42: 740-9. PMID:16909634
Malhotra P, Jäger HR, Playford ED, Brown MM, Driver J, Husain M. (2005) Spatial Working Memory Capacity in Unilateral Neglect. Brain 128: 424-435. PMID:15644422
Mannan S, Mort D, Hodgson T, Driver J, Kennard C, Husain M. (2005) Revisiting previously searched locations in visual neglect: Role of right parietal and frontal lesions in misjudging old locations as new. Journal of Cognitive Neuroscience 17: 340-354. PMID:1581124
Jackson S, Newport R, Mort D, Husain M. (2005) Where the eye looks, the hand follows: limb-dependent magnetic misreaching in optic ataxia. Current Biology 15: 42-46. PMID:15649363
Kristjansson A, Vuilleumier P, Malhotra P, Husain M, Driver J. (2005) Priming of colour and position during visual search in unilateral spatial neglect. Journal of Cognitive Neuroscience 17: 859-873. PMID:15969905
Russell C, Malhotra P, Husain M. (2004) Attention modulates the visual field in healthy observers and parietal patients. Neuroreport 15:2189-93. PMID:15371731
Malhotra P, Mannan S, Driver J, Husain M. (2004) Impaired spatial working memory: One component of the visual neglect syndrome? Cortex 40: 667-676. PMID:15505977
Wojciulik E, Rorden C, Clarke K, Husain M, Driver J. (2004) Group study of an "undercover" test for visuospatial neglect: invisible cancellation can reveal more neglect than standard cancellation. Journal of Neurology, Neurosurgery & Psychiatry 75:1356-8. PMID:15314135 PMC1739211
Jackson GM, Swainson R, Mort D, Husain M, Jackson SR. (2004) Implicit processing of global information in Balint's Syndrome. Cortex 40: 179-80. PMID:15174462
Hillstrom A, Husain M, Shapiro K, Rorden C. (2004) Spatiotemporal dynamics of attention in visual neglect: A case study. Cortex 40: 433-440. PMID:15259324
PavaniF, Husain M, Ladavas E, Driver J. (2004) Auditory deficits in visuospatial neglect patients. Cortex 40: 347-365. PMID:15156793
Husain M, Parton A, Hodgson T, Mort D, Rees G. (2003) Self-control during response conflict by human supplementary eye field. Nature Neuroscience 6:117-8. PMID:12536212
Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, Husain M. (2003) The anatomy of visual neglect. Brain 126: 1986-97. PMID:12821519
Maravita A, McNeil J, Malhotra P, Greenwood R, Husain M, Driver J. (2003) Prism adaptation can improve contralesional tactile perception in neglect. Neurology 60: 1829-1831. PMID:12796542
Maravita A, Clarke K, Husain M, Driver J. (2002) Active tool-use with contrlaesional hand can reduce crossmodal extinction of touch on that hand. Neurocase 8:411-6. PMID:12529450
Rees G, Wojciulik E, Clarke K, Husain M, Frith C, Driver J. (2002) Neural correlates of conscious and unconscious vision in parietal extinction. Neurocase 8:387-93. PMID:12499413
Eimer M, Maravita A, Van Velzen J, Husain M, Driver J. (2002) The electrophysiology of tactile extinction: ERP correlates of unconscious somatosensory processing. Neuropsychologia 40:2438-47. PMID:12417471
Vuilleumier P, Armony J, Clarke K, Husain M, Driver J, Dolan R. (2002) Neural response to emotional faces with and without awareness: event-related fMRI in a parietal patient with visual extinction and spatial neglect. Neuropsychologia 40: 2156-2166. PMID:12208011
Vuilleumier P, Schwartz S, Clarke K, Husain M, Driver J. (2002) Testing Memory for Unseen Visual Stimuli in Patients with Extinction and Spatial Neglect. Journal of Cognitive Neuroscience 14: 875-886. PMID:12191455
Husain M, Mannan S, Hodgson T, Wojciulik E, Driver J, Kennard C. (2001) Impaired spatial working memory across saccades contributes to abnormal search in parietal neglect. Brain 124: 941-952. PMID:11335696
Vuilleumier P, Schwartz S, Husain M, Clarke K, Driver J. (2001) Implicit processing and learning of visual stimuli in parietal extinction and neglect. Cortex 37: 741-744. PMID:11804230
Maravita A, Husain M, Clarke K, Driver J. (2001) Reaching with a tool extends visual-tactile interactions into far space: evidence from cross-modal extinction. Neuropsychologia 39: 580-585. PMID:11257283
Wojciulik E, Husain M, Clarke K, Driver J. (2001) Spatial working memory deficit in unilateral neglect. Neuropsychologia 39: 390–396. PMID: 11164877
Husain M, Mattingley J, Driver J, Rorden C, Kennard C. (2000) Distinguishing sensory and motor biases in parietal and frontal neglect. Brain 123: 1643-1659. PMID: 10908194
Jackson GM, Jackson SR, Husain M, Harvey M, Kramer T, Dow L. (2000) The coordination of bimanual prehension movements in a centrally deafferented patient. Brain 123: 380-393. PMID:10648445
Rees G, Wojciulik E, Clarke K, Husain M, Frith C, Driver J. (2000) Unconscious activation of visual cortex in the damaged right hemisphere of a parietal patient with extinction. Brain 123: 1624-1633. PMID:10908192
Maravita A, Spence C, Clarke K, Husain M, Driver J. (2000) Vision and touch through the looking glass in a case of crossmodal extinction. NeuroReport 11: 3521-3526. PMID:11095511
Walker R, Walker DG, Husain M, Kennard C. (2000) Control of voluntary and reflexive saccades. Experimental Brain Research 130: 540-544. PMID:10717796
Jackson SR, Newport R, Husain M, Harvey M. (2000) Reaching movements may reveal the distorted topography of spatial representations after neglect. Neuropsychologia 38: 500-507. PMID:10683400
Mattingley JB, Husain M, Rorden C, Kennard C, Driver J. (1998) Motor role of human inferior parietal lobe revealed in unilateral neglect patients. Nature 392: 179-182. PMID: 9515962
Walker R, Husain M, Hodgson T, Harrison J, Kennard C. (1998) Saccadic eye movement and working memory deficits following damage to human prefrontal cortex. Neuropsychologia 36: 1141-1159. PMID: 9842760
Husain M, Shapiro K, Martin J, Kennard C. (1997) Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature 385: 154-156 (accompanied by a commentary in Nature). PMID:8990117
Husain M, Kennard C. (1997) Distractor-dependent frontal neglect. Neuropsychologia 35: 829-841. PMID:9204488
Husain M, Kennard C. (1996) Visual neglect associated with frontal lobe infarction. Journal of Neurology 243: 652-657. PMID:8892067
Husain M. (1994) Is visual neglect body-centric? Journal of Neurology, Neurosurgery & Psychiatry 58: 262-263. PMID:7876879
Husain M, Stein JF. (1988) Rezsö Bálint and His Most Celebrated Case. Archives of Neurology 45: 89-93. PMID:3276300